The department of Physics at the University of Augsburg has an open position in the group of Prof. Dr. Nadine Schwierz starting?from September 1^st, 2026 as

?Postdoctoral Researcher (m/f/d)
Molecular Dynamics Simulations of Ionizable Lipid Systems and Lipid Nanoparticles
with salary 100% TV-L E13 fixed-term contract for 2 years

Project overview: Lipid nanoparticles (LNPs) represent one of the most promising technologies for the delivery of RNA-based therapeutics into cells. Despite their tremendous biomedical relevance, the molecular mechanisms underlying pH-triggered structural transitions, membrane fusion, and RNA release remain insufficiently understood. This project aims to uncover the fundamental biophysical mechanisms by which ionizable lipids regulate structural and functional behavior in ionizable lipid systems and lipid nanoparticles. The research will focus on modeling lipid systems and performing molecular dynamics (MD) simulations. In addition, the project involves the calculation of neutron and X-ray scattering signals from simulations and their quantitative comparison with experimental data.
Relevant work includes: https://doi.org/10.1073/pnas.2310491120, https://doi.org/10.1063/5.0172552, https://doi.org/10.1039/d3nr00987d

Areas of responsibility:

• Modeling and simulation of lipid systems and lipid nanoparticles (all-atom MD, constant pH, and coarse-grained simulations)
• Calculation of scattering signals from simulation data and quantitative comparison with experimental data
• Application of enhanced sampling and development machine learning algorithm to predict the scattering data of biomolecular systems.
• Teaching exercises in Physics/Biophysics.

What we offer:

• Excellent and interdisciplinary research activities in biomolecular simulations
• Close collaborations with experimental groups
• Outstanding, collaborative, and integrated environment of the greater Munich area
• Access to state-of-the-art supercomputing facilities

Job requirements:

• Graduation in Physics, Biophysics, or related field
• PhD in computational or theoretical physics or biophysics
• Expertise in: Computer simulations, molecular dynamics simulations, machine learning, and high-performance computing
• Experience with lipid systems or membrane simulations is highly desirable
• Background in scattering methods is advantageous
• Excellent English communication skills

The University of Augsburg promotes professional equality for women. Women are expressly encouraged to apply. Augsburg University is particularly committed to the compatibility of family and working life. For further information, please contact the Faculty Women's Representative. The University also tries to increase the proportion of scientists with physical disabilities. Respective applications are welcome.

Mai 15^th, 2026

to?Prof. Dr. Nadine Schwierz

Nadine.Schwierz@physik.uni-augsburg.de

/de/fakultaet/mntf/physik/groups/cbio/research/

Please note that only the German version of the job advertisement is legally binding, which can be found on the website: /de/jobs-und-karriere/stellenangebote.?This English translation of the job advertisement is provided to help you understand the original German one.?