In diesem Semester wird die im WiSe 2022/23 erfolgreich gestartete Vortragsreihe Medical Information Sciences fortgesetzt. Renommierte Wissenschaftlerinnen und Wissenschaftler unterschiedlicher Fachdisziplinen und Forschungsstandorte geben jeden Donnerstag ab 16:00 Uhr Einblicke in aktuelle Fragestellungen und Anwendungsgebiete des breiten Forschungsfeldes Medical Information Sciences.

Chimeric Antigen Receptor (CAR) T-cell therapy has become a promising option for patients with relapsed or refractory lymphoma. This and similar types of cellular immunotherapies are being investigated for many other cancers, such as acute leukemias. Mathematical modeling provides a useful tool for analyzing the interactions of these ‘living drugs’ with targeted cancer cells and the diverse immune or inflammatory contexts of patients. By integrating longitudinal data from experiments and clinical or laboratory studies, we examine how various, potentially patient-specific CAR T cell and cancer phenotypes interact with heterogeneous tumors, how these interactions can be inferred, and how they affect outcomes.